翻訳と辞書 Words near each other ・ Steroid-lactonase ・ Steroid-transporting ATPase ・ Steroidogenic acute regulatory protein ・ Steroidogenic factor 1 ・ Steroids (journal) ・ SteroidsOrHeroin ・ Sterol ・ Sterol 12alpha-hydroxylase ・ Sterol 14-demethylase ・ Sterol 24-C-methyltransferase ・ Sterol 3beta-glucosyltransferase ・ Sterol carrier protein ・ Sterol ester ・ Sterol esterase ・ Sterol O-acyltransferase ・ Sterol regulatory element-binding protein ・ Sterol regulatory element-binding protein 1 ・ Sterol regulatory element-binding protein 2 ・ Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) ・ Sterol-C5-desaturase-like ・ Sterol-sensing domain ・ Sterolibacterium ・ Sterolibacterium denitrificans ・ Sterolin ・ Steropanus ・ Sterope ・ Sterope (Pleiad) ・ Steropodon ・ Steropodontidae ・ Steropoides Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sterol regulatory element-binding protein ： ウィキペディア英語版 Sterol regulatory element-binding protein Sterol regulatory element-binding proteins (SREBPs) are transcription factors that bind to the sterol regulatory element DNA sequence TCACNCCAC. Mammalian SREBPs are encoded by the genes ''SREBF1'' and ''SREBF2''. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs are attached to the nuclear envelope and endoplasmic reticulum membranes. In cells with low levels of sterols, SREBPs are cleaved to a water-soluble N-terminal domain that is translocated to the nucleus. These activated SREBPs then bind to specific sterol regulatory element DNA sequences, thus upregulating the synthesis of enzymes involved in sterol biosynthesis. Sterols in turn inhibit the cleavage of SREBPs and therefore synthesis of additional sterols is reduced through a negative feed back loop. == Isoforms == Mammalian genomes have two separate SREBP genes ( and ): * SREBP-1 expression produces two different isoforms, SREBP-1a and -1c. These isoforms differ in their first exons owing to the use of different transcriptional start sites for the SREBP-1 gene. SREBP-1c was also identified in rats as ADD-1. SREBP-1c is responsible for regulating the genes required for ''de novo'' lipogenesis. * SREBP-2 regulates the genes of cholesterol metabolism. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sterol regulatory element-binding protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.